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The inhibition of PDE5 in some of these tissues by viagra may be the basis for the enhanced platelet antiaggregatory activity of ephedrine NO observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo . In addition to human corpus cavernosum smooth muscle, PDE5 is also found in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle, brain, heart, liver, kidney, lung, pancreas, prostate, bladder, testis, and ephedrine seminal vesicle .